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Thiolated Glycol Chitosan

TNF-α gene silencing using polymerized siRNA/thiolated glycol nanoparticles for rheumatoid arthritis. Lee SJ(1), Lee A(2), Hwang SR(3), Park JS(4), Jang J(4), Huh MS(5), Jo DG(4), Yoon SY(6), Byun Y(7), Kim SH(1), Kwon IC(8), nbsp; Glycol chitosan nanoparticles as specialized cancer therapeutic (c) Synthetic scheme of thiolated glycol chitosan (tGC) by chemical conjugation of Sulfo-LC-SPDP to the amine group of GC polymers. (d) Schematic illustration of fthe ormulation process of small and compact Poly-siRNA/tGC complexes. First, weak charge interactions occur between negatively charged nbsp; TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol (tGC) polymers for the treatment of RA. Poly-siRNA is prepared through self-polymerization of thiol groups at the 5 end of sense and antisense strand of siRNA and encapsulated into tGC polymers, nbsp; Nanoparticles of glycol chitosan and its thiolated derivative A novel thiomer derivative of glycol chitosan (GCS) was synthesized by coupling with thioglycolic acid (TGA) and evaluated for the pulmonary delivery of peptides. Nanoparticles (NPs) based on GCS and GCS TGA were obtained by the ionic gelation method and demonstrated a particle size in the range of nbsp; a) Chemical structure of glycol chitosan nanoparticles with reducible nanoparticles with reducible thiol linkages. Figure 1. Jablonski diagram illustrating photophysical processes. The red labels indicate where intermolecular interactions middot; Figure 2. Generalized energy-level diagram of triplet triplet annihilation (TTA) middot; Figure 3. (a) Illustration showing the nbsp; Permeability properties of glycol chitosan membrane modified with Water-soluble glycol chitosan (GC), having the ability to form a membrane, was modified with 3, 3 -dithiodipropionic acid (DTPA), a functional group that causes the thiol disulfide transition through redox reaction. The membrane derived from this modified GC was water-insoluble. The permeabilities of nbsp; Permeability properties of glycol chitosan membrane modified with (GC) , having the ability to form a membrane, was modified with 3, 3 39;-dithiodipropionic acid (DTPA) , a functional group that causes the thiol disulfide transition through redox reaction. The membrane derived from this modified GC was water- insoluble. The permeabilities of KCl and sucrose nbsp; Synthesis, Characterization and In Vitro Evaluation of a Novel Glycol Recently, glycol chitosan has been proved to have the ability to stabilize lipid rafts in the intestinal brush border and to inhibit the P-glycoprotein efflux pump through membrane binding 4, 5 . Covalent attachment of functional molecules, such as enzyme inhibitors and thiol bearing ligands, to chitosan has nbsp; pH-responsive thiolated chitosan nanoparticles for oral low (CS) with 396. 97 54. 54 μmol thiol groups per gram of polymer and then nbsp; Chitosan-based siRNA delivery systems – Université catholique de NPs were formulated to deliver polymerized siRNA (12 siRNA linked together). The particulari- ties of this polymerized siRNA are its high MW and its increased number of anionic charges, which helps enhance the NP stability in vivo. Biodistribution in SCC7 tumor-bearing mice nbsp;

Cancer-targeted MDR-1 siRNA delivery using self-cross-linked

To achieve an efficient siRNA delivery in vivo, self-polymerized 5 -end thiol-modified siRNA (poly-siRNA) was incorporated in tumor targeting glycol chitosan nanoparticles. Pgp-targeted poly-siRNA (psi-Pgp) and thiolated glycol chitosan polymers (tGC) formed stable nanoparticles (psi-Pgp-tGC NPs), and nbsp; An in situ forming tissue adhesive based on poly(ethylene glycol )-methacrylate (PEGDMA) and thiolated chitosan (CSS) was prepared. PEGDMA and CSS cross-linked rapidly under physiological conditions through the Michael addition reaction via UV lamp irradiation. The chemi. Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent For this purpose, the glycol chitosan-N-acetyl-cysteine (GCS-NAC) and glycol chitosan-glutathione (GCS-GSH) thiomers were prepared under simple and mild nbsp; Nanoparticles of glycol chitosan and its thiolated derivative (GCS) was synthesized by coupling with thioglycolic acid (TGA) and evaluated for the pulmonary delivery of peptides. Nanoparticles (NPs) based on GCS and GCS-TGA were obtained by the ionic gelation method and demonstrated a particle size in the range of 0. 23-0. 33 microm nbsp; Dual Secured Nano-Melittin for Safe and Effective Eradicating . Glycol chitosan (Mw: 200 kDa) was first depolymerized to Mw 28 kDa using potassium persulfate, and then amidized and thiolated by reacting with succinic anhydride and SPDP sequentially. Briefly; glycol chitosan (400 mg) was dissolved in 37. 5 ml of hydrochloric acid. (2 , v/v). Publications about Thiomers – ThioMatrix -polyethylene glycol) chitosan graft polymer for drug delivery. J. Pharm. Sci. , 103, 594-601. Hauptstein, S. , Müller, C. , Dünnhaupt, S. , Laffleur, F. , Bernkop-Schnürch, A. (2013) Preactivated thiomers: evaluation of gastroretentive minitablets. Int. J. Pharm. , 456, 473-479. Nanoparticles Based on Chitosan Derivatives – InTechOpen coupled with thioglycolic acid (TGA) was ionotropically gelled with TPP to yield nanoparticles, which showed a twofold increase in mucoadhesion to lung tissue after intra-tracheal administration to rats as compared to non-thiolated nanoparticles. Biocompat ibility of nanoparticle formulations with lung tissue nbsp; A. Makhlof – Google Scholar Citations and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. A Makhlof, M Werle, Y Tozuka, H Takeuchi. International journal of pharmaceutics 397 (1-2), 92-95, 2010. 89, 2010. In vitro and in vivo evaluation of WGA carbopol modified liposomes as carriers for oral nbsp; Chitosan – Wikipedia /ˈkaɪtəsæn/ is a linear polysaccharide composed of randomly distributed β-(1 4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, like sodium hydroxide. Chitosan has a nbsp; Synthesis and Characterization of New Thiolated Chitosan – Hindawi To achieve this goal, it is important to use biocompatible polymers, for example, polyethylene glycol (PEG) 10 , chitosan 11 , and poly(lactic-co-glycolic acid) (PLGA) 12 . Nowadays, it is a challenge to design monodisperse and stable polymeric particles useful in certain applications, including cancer nbsp; Thiolated Chitosan – SM Group Open Access eBooks D-Α-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer (PLA-PCL-TPGS);. Polymethyl Methacrylate (pMMA); Paclitaxel (PTX); Thiolated Chitosan (TCH); Thioglycolic. Acid (TGA); Homocysteine Thiolactone (HT); N, N, N-Trimethyl-Chitosan (TM-CH); Sodium. Tripolyphosphate (TPP) nbsp;

Improvement of curcumin solubility by polyethylene glycol/chitosan

Improvement of curcumin solubility by polyethylene glycol/chitosan-gelatin nanoparticles (CUR-PEG/CS-G-nps). Poopak Farnia1, 2, Saeed Mollaei3, Afshin Bahrami1, Alireza Ghassempour4, Ali Akbar Velayati1, . Jalaledin Ghanavi1, 2 . 1Mycobacteriology Research Center, National Research Institute of nbsp; Chitosan Nanoparticles – Springer – Springer Link In addition, both modifications have been used as nonviral carrier systems to combine the advantages of trimethyl chitosan and thiolated chitosan while Hydrophobic moieties can also be attached to chitosan to facilitate the incorporation of insoluble drugs, i. e. , hydrophobic glycol chitosan nanoparticles. Chitosan and Chitosan Derivatives in Drug Delivery and Tissue a synthetic route for the preparation of thiol-bearing TMC 35, 36 . Indeed, the presence of thiol increased the muco-adhesion of chitosan derivatives by formation of a disulfide bond with mucin . N-octyl-O-glycol-chitosan by successive reaction of chitosan chains with N-octyl- aldehyde followed by the ring nbsp; Thiol Polyethylene Glycol – Journal of Pharmaceutical Sciences (Thiol Polyethylene Glycol) Chitosan Graft Polymer for Drug. Delivery. SABINE HAUPTSTEIN, 1 SONJA BONENGEL, 1 JULIA GRIESSINGER, 2 ANDREAS BERNKOP-SCHN URCH1. 1Center for Chemistry and Biomedicine, Center for Molecular Biosciences, Department of Pharmaceutical Technology, . Chitosan based hydrogels: characteristics and pharmaceutical . Adipose-derived stem cells. Soft tissue . . Thiolated chitosan. One of important modifications on chitosan to increase its mucoadhesiveness is thilation of chitosa. By thiolation, -SH groups are. Thiolated chitosan-modified PLA-PCL-TPGS nanoparticles for oral In this research, our group proposed a new type of polymeric nanoparticles, i. e. , biodegradable poly(lactide-co ε-caprolactone)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-PCL-TPGS) nanoparticles modified with thiolated chitosan for oral chemotherapy using paclitaxel as a therapeutic agent nbsp; Full text pH-responsive glycol chitosan-cross-linked carboxymethyl pH-responsive glycol chitosan-cross-linked carboxymethyl-Î -cyclodextrin nanoparticles for controlled release of anticancer drugs Yiwen Wang, Fei Qin, Haina Tan, Yan Zhang, Miao Jiang, Mei Lu, Xin Yao School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, nbsp; Novel injectable biodegradable glycol chitosanbased hydrogels Abstract: Novel injectable biodegradable glycol chitosan hydrogels were developed based on thiolated glycol chito- san (GC-SH) and water soluble oligo(acryloyl carbonate)-b- poly(ethylene glycol)-b-oligo(acryloyl carbonate) (OAC-PEG-. OAC) triblock copolymers via Michael-type addition reaction. Synthesis and Characterization of pH-Sensitive Thiol-Containing -Containing Chitosan Beads for Controlled Drug. Delivery Applications. R. Jayakumar, R. L. Reis, . on thiolated-chitosan particles or beads and its applications in the delivery of drugs and other substances. . The reducing thiol functions on the chitosan backbone enable the glycol proteins to also form inter- as well nbsp;

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